Turn biological complexity into ranked actions.
Metastate Brain is a decision system for biology teams who cannot afford blind iteration. We combine constraints, mechanistic reasoning, and data signals to answer one question: what should you do next, and why.
This is not another dashboard or tool suite. It is a way to compress uncertainty into a short list of experiments and interventions, deployed through focused programs.
- Identify the dominant constraint or leverage point under real bounds.
- Translate messy signals into ranked hypotheses and actions.
- Deliver a minimum experiment set that collapses uncertainty.
What Metastate Brain is
A repeatable way to turn biological complexity into decision ready actions.
Most biology teams do not fail because they lack data. They fail because they cannot convert partial signals into a confident next step. Metastate Brain is designed to do exactly that.
We start by framing the system under real constraints. Then we rank plausible mechanisms and interventions using mechanistic reasoning plus whatever data is available. Finally, we output a minimum experiment set that resolves the decision.
You keep IP. Work happens in private, project-specific workspaces. The commercial unit is the program, not an annual software license.
Programs deliver
- Decision memo with ranked actions.
- Evidence map that shows what is known and unknown.
- Minimum experiment set to resolve the decision.
- Handoff session with failure modes and branches.
Where teams get stuck
If two of these feel familiar, you do not need more data. You need a decision loop.
Endless iteration
You have plenty of hypotheses, but no decision rule. Experiments keep happening, confidence never rises.
Local optimization traps
You optimize a proxy, then scale breaks the story. What worked in one regime fails under real bounds.
Data without decisions
You have omics, models, dashboards, and logs, but nobody can say what to do next with conviction.
Start here
If the problem is upstream, strain, or scale-up divergence, start with the Bioprocess Diagnostic Sprint. If the problem is experiment planning under constraints, start with DOE Set Builder.
Programs
Choose the program that matches the decision you are stuck on.
Bioprocess Diagnostic Sprint
Start hereFind the dominant constraint in your upstream process and the next 3 to 5 experiments to run.
Best for: Upstream PD, strain teams, tech transfer, scale up divergence, titer plateaus.
Engagement: Fixed scope, 4 weeks.
View programDOE Set Builder
OptimizationDesign high information experiments under real throughput, cost, and time constraints.
Best for: Teams running expensive experimental loops who need clean factor selection and decision rules.
Engagement: Rapid engagement or embedded support.
View programPeptide-Lab
Partner programStage gated short peptide discovery and prioritization for GLP-1 secretion targets.
Best for: Partners who can run validation assays and want a disciplined candidate prioritization pipeline.
Engagement: Partnership-driven validation program.
View programSynthetic Lethality Program
DiscoveryRank synthetic lethal hypotheses and produce a minimal validation plan.
Best for: Discovery teams who need interpretable hypotheses, not just model output.
Engagement: Project-based.
View programPersonalized Metabolomics
IndividualA metabolomics snapshot translated into actionable hypotheses for lifestyle and intervention experiments.
Best for: Individuals and research teams running structured self experiments.
Engagement: Report plus optional follow on.
View programLearn before you talk
Two short examples to calibrate how we think and what "decision-grade" looks like.
Example decision memo
A 2-page anonymized template showing ranked hypotheses, evidence map, and a 3-5 run experiment set.
We'll email it to you.
DOE matrix checklist
A one-page pre-flight that prevents DOEs that look scientific but do not change decisions.
We'll email it to you.
Peptide-Lab whitepaper
Public technical overview of Peptide-Lab and its stage-gated prioritization approach.
We'll email it to you.
How the Brain works
A simple loop that prevents endless iteration.
Frame the system
Define the decision, constraints, and what success means under real operating bounds.
Rank mechanisms and actions
Generate plausible explanations and interventions, then rank them with explicit uncertainty.
Collapse uncertainty fast
Output the smallest experiment set that changes the decision and reduces wasted cycles.
What you get
Every program ends with a decision package your team can execute.
- Decision memo. What is most likely true, what is not, and what to do next.
- Ranked actions. Experiments or interventions ordered by expected value and risk.
- Evidence map. Signals that support each hypothesis and what is still unknown.
- Handoff. Walkthrough with your team, including failure modes and next branches.
News and milestones
Recent updates across Metastate Brain programs.
Tell us the decision you are trying to make.
Book a 15 minute intro call. We will route you to the right program, confirm minimum inputs, and outline a realistic first engagement.
See if this applies to your case
Share a few details. We'll reply with (1) whether we're a fit, (2) the best starting program, and (3) the minimum inputs to begin.